HIV-associated Hodgkin lymphoma: a clinicopathologic and immunophenotypic study of 45 cases.

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作者：

LDR Thompson，SI Fisher，SC Wei，A Nelson，SL Abbondanzo

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摘要：

We retrospectively analyzed 45 cases of -associated (-). -generally is a disease of young white men (mean age, 40.1 years) who acquired by homosexual or bisexual (68%), intravenous drug use (24%), and/or blood transfusion (8%). The mean interval between the diagnosis of and -was 5.2 years. Morphologic classification of biopsy specimens (2001 World Health Organization criteria) included 15 mixed cellularity (), 14 nodular sclerosis (), 9 lymphocyte depleted (), and 7 classic , type not further categorized. The Hodgkin-Reed-Sternberg () cells expressed positive immunoreactivity with (30/30 [100%]), (35/37 [95%]), CD15 (32/36 [89%]), bcl-X(L) (25/31 [81%]), (15/29 [52%]), (4/34 [12%]), (3/28 [11%]), and (32/33 [97%]) and were nonreactive for CD138/syndecan-1. and CD8 immunostaining showed an inverted /CD8 ratio (<1/20) in all cases. At diagnosis, most patients (n = 27) had high-stage disease (IV(E)) associated with an aggressive course (16% 5-year survival). behaved more aggressively than and (15% vs 40%, 5-year survival, respectively), as did disease with a sarcomatoid pattern (11% 5-year survival). Chemotherapy and radiotherapy proved efficacious in a minority of these patients.

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关键词：

Humans Lymph Nodes Reed-Sternberg Cells HIV Infections Hodgkin Disease Lymphoma, AIDS-Related DNA, Viral Survival Rate Tumor Markers, Biological Retrospective Studies