LACTATE DEHYDROGENASE AS A NOVEL TARGET AND REAGENT FOR DIABETES THERAPY

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申请(专利)号：

WO2004US01452

申请日期：

2004-01-21

公开/公告号：

WO2004071405A2

公开/公告日期：

2004-08-26

申请(专利权)人：

DUKE UNIVERSITY;BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM;NEWGARD, CHRISTOPHER, B.;JENSEN, METTE, V.;SHERRY, A., DEAN;BURGESS, SHAWN, C.

发明人：

NEWGARD Christopher B.，JENSEN Mette V.，SHERRY A. Dean，BURGESS Shawn C.

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摘要：

The present invention provides an isolated nucleic acid encoding a novel lactate dehydrogenase (LDH) as well as the isolated LDH polypeptide. Also provided are methods of enhancing fuel-stimulated insulin secretion, in particular, glucose-stimulated insulin secretion. Further provided are methods of screening for compounds that bind LDH, modulate LDH activity, and/or modulate fuel- or glucose-stimulated insulin secretion and the compounds identified thereby. The invention further provides a method of enhancing insulin secretion by administering a nucleic acid encoding LDH to a subject in a therapeutically effective amount.

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