摘要：

Inany partsfhe nervousystem, neuronalomata displayrderlypatialrrangements. Inheetina, neuronsf numerous individualubtypesormegularrraysalledosaics:heyre less likelyoe near neighboursfheameubtypehan wouldccuryhance,esulting in 'exclusion zones'hateparatehem.osaicrrangements provideechanismo distribute eachellype evenlycrossheetina, ensuringhatll partsfhe visualieldaveccessoulletf processing elements.emarkably,osaicsre independentf eachther:lthough neuronfneubtype isnlikelyoedjacentonotherfheameubtype,here is noestrictionn itspatialelationshipo neighbouring neuronsftherubtypes.his independenceas ledoheypothesishatolecularues expressedypecificubtypes patternosaicsyediatingomotypic (within-subtype)hort-rangeepulsive interactions.oar,owever, nooleculesaveeen identifiedhathowuchctivity,ohisypothesisemainsntested.ere we demonstrate inousehatwoelatedransmembrane proteins,EGF10ndEGF11,averiticaloles inheormationfosaicsywoetinal interneuronubtypes,tarburstmacrineellsndorizontalells.EGF10nd 11ndheir invertebrateelativesaenorhabditis elegansED-1nd Drosophila Draperaveithertoeentudied primarilyseceptors necessaryor engulfmentf debrisollowingpoptosisrxonal injury.uresults demonstratehatembersfhis geneamilyanlsoervesubtype-specific ligandshat pattern neuronalrrays.

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