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Plasma cell differentiation requires the transcription factor XBP-1.

来自 EBSCO

阅读量：

175

作者：

AM Reimold，NN Iwakoshi，J Manis，P Vallabhajosyula，LH Glimcher

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摘要：

Considerable progress has been made in identifying the transcription factors involved in the early specification of the B-lymphocyte lineage. However, little is known about factors that control the transition of mature activated B cells to antibody-secreting plasma cells. Here we report that the transcription factor XBP-1 is required for the generation of plasma cells. XBP-1 transcripts were rapidly upregulated in vitro by stimuli that induce plasma-cell differentiation, and were found at high levels in plasma cells from rheumatoid synovium. When introduced into B-lineage cells, XBP-1 initiated plasma-cell differentiation. Mouse lymphoid chimaeras deficient in XBP-1 possessed normal numbers of activated B lymphocytes that proliferated, secreted cytokines and formed normal germinal centres. However, they secreted very little immunoglobulin of any isotype and failed to control infection with the B-cell-dependent polyoma virus, because plasma cells were markedly absent. XBP-1 is the only transcription factor known to be selectively and specifically required for the terminal differentiation of B lymphocytes to plasma cells.

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关键词：

B-Lymphocytes Plasma Cells Animals Chimera Mice Polyomavirus Arthritis, Rheumatoid Inflammation DNA-Binding Proteins Transcription Factors

DOI：

10.1038/35085509

被引量：

2771

年份：

2001

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来源期刊

Nature
2001

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2009
被引量：215

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