The role of ubiquitylation in immune defence and pathogen evasion.
摘要：
Ubiquitylation is a widely used post-translational protein modification that regulates many biological processes, including immune responses. The role of ubiquitin in immune regulation was originally uncovered through studies of antigen presentation and the nuclear factor-κB family of transcription factors, which orchestrate host defence against microorganisms. Recent studies have revealed crucial roles of ubiquitylation in many aspects of the immune system, including innate and adaptive immunity and antimicrobial autophagy. In addition, mounting evidence indicates that microbial pathogens exploit the ubiquitin pathway to evade the host immune system. Here, we review recent advances on the role of ubiquitylation in host defence and pathogen evasion.
展开
关键词：
Animals Humans Antigen Presentation Protein Processing, Post-Translational Adaptive Immunity Immune Evasion Ubiquitination Autophagy Immunity, Innate Ubiquitin
DOI：
10.1038/nri3111
被引量：
年份：
2012
Nature
(全网免费下载)
Nature
国家科技图书文献中心
(权威机构)
掌桥科研
万方医学
查看更多
doi.org
Ingenta
NCBI
Europe PMC
(全网免费下载)
NCBI
Europe PMC
ResearchGate
ProQuest
EBSCO
EBSCO
jem.rupress.org
hw-f5-embor.highwire.org
mendeley.com
plantphysiol.org
embor.embopress.org
scienceopen.com
ftp.palgrave-journals.com
mysciencework.com
pubfacts.com
go.galegroup.com
utsouthwestern.influuent.utsystem.edu
readcube.com
www.socolar.com
onAcademic
ar.newsmth.net
(全网免费下载)
学术范
exp.newsmth.net
(全网免费下载)
jacionline.org
学术范
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
