摘要：

The quality, duration and cardiorespiratory effects of 3 anaesthetic drugs were determined in 15 healthy adult male dogs. Dogs were divided into 3 equal groups, each group was intravenously administered a combination of 2 of the following drugs: midazolam (0.3 mg/kg), medetomidine (20 g/kg) and ketamine (10 mg/kg). Induction, anaesthetic and recovery times were recorded. Heart rate, systolic and diastolic blood pressures, respiratory rate, percent saturation of haemoglobin with oxygen (SpO2%), rectal body temperature and blood glucose were traced before and at 5, 10, 15, 30, 45, 60, 90 and 120 minutes after drugs administration. The results revealed that, medetomidine + midazolam combination showed the longest anaesthetic time (43.4±3.5 min), while midazolam + ketamine combination revealed the shortest anaesthetic time (22.8±3.6 min). Medetomidine + ketamine combination caused the least alteration of the heart rate, while midazolam + ketamine combination produced the least changes in the haemoglobin oxygen saturation. Slight dyspnoea and vomiting were observed in some dogs administered medetomidine + ketamine, while dropped eye ball was seen after medetomidine + midazolam injection. The 2 combinations those had medetomidine showed slight elevations in blood glucose. The results concluded that combining ketamine with medetomidine or midazolam decreases their suppressive effect on cardiovascular system and improves the quality of anaesthesia.

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