New Insights into the Role of Nuclear Factor-??B, a Ubiquitous Transcription Factor in the Initiation of Diseases
摘要：
Nuclear factor-kappaB (NF-kappaB) is a ubiquitous transcription factor that governs the expression of genes encoding cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NF-kappaB is activated by several agents, including cytokines, oxidant free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-kappaB has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-kappaB has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth. Therefore, development of modulatory strategies targeting this transcription factor may provide a novel therapeutic tool for the treatment or prevention of various diseases.
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关键词：
Animals Humans Inflammation Phosphotransferases NF-kappa B Embryonic and Fetal Development Apoptosis Neoplasms
DOI：
10.1093/clinchem/45.1.7
被引量：
年份：
1999
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