Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine

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阅读量：

163

作者：

MH Mirjalili，E Moyano，M Bonfill，RM Cusido，J Palazón

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摘要：

Withania somnifera, commonly known as Ashwagandha, is an important medicinal plant that has been used in Ayurvedic and indigenous medicine for over 3,000 years. In view of its varied therapeutic potential, it has also been the subject of considerable modern scientific attention. The major chemical constituents of the Withania genus, the withanolides, are a group of naturally occurring C28-steroidal lactone triterpenoids built on an intact or rearranged ergostane framework, in which C-22 and C-26 are appropriately oxidized to form a six-membered lactone ring. In recent years, numerous pharmacological investigations have been carried out into the components of W. somnifera extracts. We present here an overview of the chemical structures of triterpenoid components and their biological activity, focusing on two novel activities, tumor inhibition and antiangiogenic properties of withaferin A and the effects of withanolide A on Alzheimers disease. The most recent attempts in biotechnological production of withanolides are also discussed.

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关键词：

Withania somnifera withanolides withaferin A withanolide A triterpenoids

DOI：

10.3390/molecules14072373

被引量：

453

年份：

2009