CD200 is a new prognostic factor in multiple myeloma.
摘要：
Using Affymetrix microarrays, we identified the expression of the CD200 gene in multiple myeloma cells (MMCs) of 112 patients with newly diagnosed multiple myeloma (MM). The CD200 gene was either absent or present (Affymetrix call) in 22% and 78% of MMCs, respectively. The CD200 gene is not expressed in cells of the patients' bone marrow (BM). CD200 is a membrane glycoprotein that imparts an immunoregulatory signal through CD200R, leading to the suppression of T-cell-mediated immune responses. Patients with CD200(absent) MMCs have an increased event-free survival (EFS; 24 months) compared with patients with CD200(present) MMCs (14 months), after high-dose therapy and stem cell transplantation. In a Cox proportional-hazard model, the absence or presence of CD200 expression in MMCs is predictive for EFS for patients independently of ISS stage or beta2M serum levels. Thus, CD200 is an independent prognosis factor for patients with MM that could represent a new therapeutic target in MM.
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关键词：
Humans Bone Marrow Cells Oligonucleotide Array Sequence Analysis Tumor Markers, Biological Predictive Value of Tests Gene Expression Profiling Gene Expression Regulation, Neoplastic Cell Line, Tumor Antigens, CD Multiple Myeloma
DOI：
10.1182/blood-2006-06-029355
被引量：
年份：
2006
Taylor & Francis
万方医学
掌桥科研
Semantic Scholar
万方医学
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