Mechanisms of caspase activation.
摘要：
The core effectors of apoptosis encompass proteolytic enzymes of the caspase family, which reside as latent precursors in most nucleated metazoan cells. A majority of studies on apoptosis are based on the assumption that caspase precursors are activated by cleavage, a common mechanism for most protease zymogen activations. Although this appears to be true for the executioner caspases, recent research points to a distinct activation mechanism for the initiator caspases that trigger the apoptotic pathways. This mechanism is proximity-induced dimerization without cleavage, and its elucidation has led to the revision of concepts of feedback regulation of apoptosis.
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关键词：
Apaf-1 apoptotic protease activating factor apoptotic protease activating factor CARD caspase-activation recruitment domain caspase-activation recruitment domain DED death effector domain death effector domain DISC death-inducing signaling complex death-inducing signaling complex FADD fas-associated protein with death domain fas-associated protein with death domain
DOI：
10.1016/j.ceb.2003.10.009
被引量：
年份：
2003
Taylor & Francis
Elsevier
万方
掌桥科研
Ingenta
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