摘要：

Organozinc reagents have been used as a reliable tool to construct new C C covalent bonds owing to their ease of availability and high chemoselectivity. In the first section of this chapter, recent advances in the catalytic asymmetric addition reactions of organozinc reagents to the C X π bonds (X=O, N) are summarized together with some applications. These are classified according to particular organozinc compound, substrate, and chiral ligand, with the aim of providing a guide to aid selection of potential chiral ligands for addition reactions. Furthermore, relatively new aspects of organozinc addition, autocatalytic, and chirality switching reactions are discussed. In the second part of the chapter, recent advances regarding Reformatsky reagents are introduced with reference to their application to asymmetric reactions. Further expansion of this reaction for the synthesis of chiral fluorinated amino acids is also presented. As a final topic, radical reactions mediated by dialkylzinc reagents, which provide unique reactivity and selectivity compared with other radical initiators, are discussed.

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