摘要：

The metabolism of d- and l-3-hydroxybutyrate by neonatal and suckling rats was investigated. Both isomers of 3-hydroxybutyrate were incorporated into hepatic lipid, amino acids, and protein throughout the developmental period. The enzyme activities of liver 3-oxo-CoA transferase and brain 3-hydroxybutyrate dehydrogenase were compared during the first 3 postnatal weeks. The results suggest that the enzymatic activity of liver 3-oxo-CoA transferase is sufficient to account for a major portion of the d-isomer incorporation. The production of CO 2 by rat liver was greater from d-3-hydroxybutyrate than that measured from the l-isomer. The in vitro oxidation of both the d- and l-isomers by rat liver was stimulated by ATP + CoA or by GTP + CoA which suggests that their utilization may also be mediated by acyl-CoA synthetase enzymes.

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