摘要：

OBJECTIVE To synthesis the new organic tin compound containing silicon and to test its antibacterial activity. METHODS Four novel organotin compounds containing silicon were synthesized by reaction of corresponding salicylaldehyde semicarbazones with(Me3Si CH2)2Sn Cl2 at room temperature, respectively. The products were characterized by IR, NMR and X-ray diffraction. The antibacterial activity of the products were evaluated by disk diffusion method. RESULTS Salicylaldehyde semicarbazone ligands chelated the tin atom in the form of tridentate ligand, central tin atom was pentacoordinate trigonal bipyramidal structure. Antibacterial experiment showed that 3 compounds showed inhibitory effect against G+ bacteria: Staphylococcus aureus and Bacillus cereus G+ and fungus Verticillium lecanii. The antibacterial ring of compound 3 against Staphylococcus aureus was 20 mm and minimum inhibitory concentration was 25.17 mol·L?1, furthermore the study also showed that the compounds had no inhibitory effect on G? bacteria including Escherichia coli, Typhoid bacillus and Enterobacter aerogenes. CONCLUSION Salicylaldehyde semicarbazone organotin compounds containing silicon has certain antibacterial activity against G+ bacteria including Staphylococcus aureus and fungus Verticillium lecanii, without inhibitory effect on G? bacteria.

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