Stereoselective synthesis of iso-dolaproine via dynamic kinetic resolution
摘要：
see reaction]. An efficient multigram-scale synthesis of optically pure Boc-(2S,3R,4S)-iso-dolaproine is reported using dynamic kinetic resolution (DKR). The catalytic asymmetric hydrogenation of ethyl (4S)-3-(2'-pyrrolidinyl)-3-oxo-2-methyl propanoate hydrochloride using in situ generated Ru[(S)-MeO-BIPHEP]Br2 catalyst affords the anti beta-hydroxy alpha-methyl ester quantitatively. The two new stereogenic centers are simultaneously controlled with high diastereoselectivity.
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关键词：
amino acids, peptides diastereoselective syntheses, enantioselective syntheses (incl. ci/trans-isomerism
DOI：
10.1021/ol015955g
被引量：
年份：
2001
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