Enantioselective Aza‐Henry Reaction with Acyclic Guanidine‐Thiourea Bifunctional Organocatalyst
摘要:
A highly enantioselective aza-Henry reaction of imines with nitromethane was achieved with a reactive guanidine-thiourea bifunctional organocatalyst affording -nitroamines with high enantioselectivity (up to 96% ee ). The diastereo- and enantioselective version of this reaction with nitroalkanes also proceeded selectively (up to 99:1 dr with 99% ee ).
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DOI:
10.1002/adsc.200800692
被引量:
年份:
2010
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