Long-term human B cell lines dependent on interleukin-4 and antibody to CD40
摘要：
CD40 is a 45- to 50-kilodalton transmembrane glycoprotein expressed on B lymphocytes, epithelial cells, and some carcinoma cell lines. Human resting B lymphocytes entered a state of sustained proliferation when incubated with both the mouse fibroblastic Ltk$^-$ cell line that had been transfected with the human Fc receptor (FcγRII/CDw32) and monoclonal antibodies to CD40. In combination with interleukin-4, factor-dependent long-term normal human B cell lines were generated that were consistently negative for Epstein-Barr viral infection. Thus, cross-linking of CD40 is likely to represent an important phenomenon in the clonal expansion of B cells.
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关键词：
CUTANEOUS MALIGNANT MELANOMA LOSS OF HETEROZYGOSITY CHROMOSOME-9 REARRANGEMENTS ALPHA-INTERFERON AND INTERFERON-BETA GENES TUMOR-SUPPRESSOR GENES
DOI：
10.1126/science.1702555
被引量：
年份：
1991
Taylor & Francis
万方医学
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