Regulation of the T-Independent Humoral Response by TACI
摘要：
TACI is a TNFR homolog expressed by mature B lymphocytes that has been implicated in the positive regulation of B cell growth and antibody production, as well as in the development of autoimmune disease. Its biology is complex due to the existence of two ligands, BLyS and APRIL, and a homologous receptor, BCMA, that similarly binds both ligands. To determine its critical biological role, we generated TACI knockout mice. Surprisingly, these mice demonstrated a 2-fold increase in numbers of circulating and splenic B cells, apparently due to increased proliferation rate. Maturation of B cells and T-dependent antibody production was normal, but responses to T-independent type II antigens were almost completely abolished. It appears that TACI provides an essential costimulatory signal for the T-independent humoral response.
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DOI：
10.1016/S1074-7613(01)00130-3
被引量：
年份：
2001
Elsevier
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Elsevier
掌桥科研
dx.doi.org
Ingenta
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Cell Press
Oxford Univ Press
NCBI
Cell Press
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NCBI
Europe PMC
ResearchGate
ProQuest
EBSCO
bloodjournal.org
www.socolar.com
core.ac.uk
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scienceopen.com
yadda.icm.edu.pl
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jacionline.org
bbmt.org
jem.rupress.org
emboj.embopress.org
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