摘要：

A wide variety of optically active compounds as well as active compounds such as amino acid derivatives can be accessed by the cross‐Mannich reaction of aldehydes, particularly by the direct catalytic asymmetric version, in which C?C bonds are formed. Remarkable advancements have been reported, including one‐pot, three‐component procedures with absolute stereocontrol and high yields (see example, NMP=N‐methylpyrrolidine). <img class="figure__image" src="https://wol-prod-cdn.literatumonline.com/cms/attachment/e87e217d-8667-42e6-8c92-e23a2c13ee52/mcontent.gif" data-lg-src="https://wol-prod-cdn.literatumonline.com/cms/attachment/56c1e154-18e6-41fd-8a3f-9653929ea530/mcontent.jpg">

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