Microwave assisted synthesis of novel imidazolopyridinyl indoles as potent antioxidant and antimicrobial agents
摘要：
We describe herein the design, synthesis, and pharmacological evaluation of novel series of imidazolopyridinyl indole analogues as potent antioxidants and antimicrobials. These novel compounds (3a–i) were synthesized by reacting 3,5-disubstituted-indole-2-carboxylic acid (1a–i) with 2,3-diamino pyridine (2) in excellent yield. The novel products were confirmed by their IR, 1H NMR, 13C NMR, mass spectral, and analytical data. These compounds were screened for their antioxidant and antimicrobial activities. Among the compounds tested, 3a–d showed the highest total antioxidant capacity, scavenging, and antimicrobial activities. Compounds 3c-d and 3g-h have shown excellent ferric reducing activity.
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关键词：
Seven-membered ring Symmetric phosphorus ylides Suzuki cross-coupling reaction Low catalyst loading X-ray crystal structure
DOI：
10.1155/2014/579612
被引量：
年份：
2014
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