Livin/melanoma inhibitor of apoptosis protein as a potential therapeutic target for the treatment of malignancy
摘要：
Livin, also called melanoma inhibitor of apoptosis protein (IAP) or kidney IAP, is a member of the IAP family of caspase inhibitors that selectively binds the endogenous IAP antagonist SMAC and caspase-3, caspase-7, and caspase-9. As such, Livin inhibits apoptosis, and its overexpression renders malignant cells resistant to chemotherapy. Therefore, inhibitors of Livin could be useful adjuncts to chemotherapy in the treatment of malignancies. This review will discuss Livin as a potential therapeutic target and strategies for its inhibition, including antisense oligonucleotides, small-molecule inhibitors, and immune-mediated approaches.
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关键词：
Animals Humans Caspases Protein Binding Apoptosis Gene Expression Neoplasms Inhibitor of Apoptosis Proteins
DOI：
10.1158/1535-7163.MCT-06-0443
被引量：
年份：
2007
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