Pathways of protein secretion in eukaryotes
摘要：
Protein secretion from cells can take several forms. Secretion is constitutive if proteins are secreted as fast as they are synthesized. In regulated secretion newly synthesized proteins destined for secretion are stored at high concentration in secretory vesicles until the cell receives an appropriate stimulus. When both constitutive and regulated protein secretion can take place in the same cell a mechanism must exist for sorting the correct secretory protein into the correct secretory vesicle. The secretory vesicle must then be delivered to the appropriate region of plasma membrane. Transfection of DNA encoding foreign secretory proteins into regulated secretory cells has provided insight into the specificity of sorting into secretory vesicles.
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关键词：
Animals Cells Pituitary Gland Lysosomes Golgi Apparatus Eukaryotic Cells Cell Line Cytoplasmic Granules Leukemia Virus, Murine Calcium
DOI：
10.1126/science.2994224
被引量：
年份：
1985
BMJ
万方医学
Semantic Scholar
dx.doi.org
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