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SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells

来自 dx.doi.org

阅读量：

609

作者：

Mark，J.，Kiel，and，mer，H.，Yilmaz，and，Toshihide，Iwashita

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摘要：

Summary To improve our ability to identify hematopoietic stem cells (HSCs) and their localization in vivo, we compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors (MPPs). Cell surface receptors of the SLAM family, including CD150, CD244, and CD48, were differentially expressed among functionally distinct progenitors. HSCs were highly purified as CD150+CD244CD48 cells while MPPs were CD244+CD150CD48 and most restricted progenitors were CD48+CD244+CD150. The primitiveness of hematopoietic progenitors could thus be predicted based on the combination of SLAM family members they expressed. This is the first family of receptors whose combinatorial expression precisely distinguishes stem and progenitor cells. The ability to purify HSCs based on a simple combination of SLAM receptors allowed us to identify HSCs in tissue sections. Many HSCs were associated with sinusoidal endothelium in spleen and bone marrow, though some HSCs were associated with endosteum. HSCs thus occupy multiple niches, including sinusoidal endothelium in diverse tissues.

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关键词：

Bone Marrow Animals Mice, Inbred BALB C Mice, Inbred C57BL Mice Spleen Endothelial Cells Hematopoietic Stem Cells Glycoproteins Membrane Glycoproteins

DOI：

10.1016/j.cell.2005.05.026

被引量：

5138

年份：

2005

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来源期刊

Cell
2005年

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