W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity
摘要：
THE pacemaker activity in the mammalian gut is responsible for generating anally propagating phasic contractions. The cellular basis for this intrinsic activity is unknown. The smooth muscle cells of the external muscle layers and the innervated cellular network of interstitial cells of Cajal, which is closely associated with the external muscle layers of the mammalian gut, have both been proposed to stimulate pacemaker activity 1–5 . The interstitial cells of Cajal were identified in the last century but their developmental origin and function have remained unclear. Here we show that the interstitial cells of Cajal express the Kit receptor tyrosine kinase. Furthermore, mice with mutations in the dominant white spotting (W) locus, which have cellular defects in haematopoiesis, melanogenesis and gametogenesis 6 as a result of mutations in the Kit gene 7,8 , also lack the network of intestitial cells of Cajal associated with Auerbach's nerve plexus and intestinal pacemaker activity.
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关键词：
Animals Mice Connective Tissue Muscle, Smooth Intestine, Small Neurons Methylene Blue Receptors, Colony-Stimulating Factor Proto-Oncogene Proteins Signal Transduction
DOI：
10.1038/373347a0
被引量：
年份：
1995
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Springer
Nature
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Nature
万方医学
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