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Synergistic Role of Curcumin With Current Therapeutics in Colorectal Cancer: Minireview

来自 掌桥科研

阅读量：

50

作者：

Bhaumik B. Patel & Adhip P. N. Majumdar

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摘要：

Despite the use of surgical resection and aggressive chemotherapy, nearly 50% of patients with colorectal carcinoma develop recurrent disease, highlighting the need for improved therapies. Curcumin (diferuloylmethane), the major active ingredient of turmeric (curcuma longa) with no discernable toxicity, has been shown to inhibit the growth of transformed cells and colon carcinogenesis at the initiation, promotion, and progression stages in carcinogen-induced rodent models. In a Phase I clinical trial, curcumin has been found to be extremely well tolerated and effective. In this review, we summarized the current status of our knowledge about the effectiveness of curcumin when given in combination with current chemotherapeutics such as 5-fluorouracil, oxaliplatin, and gemcitabine in treatment of gastrointestinal cancers with particular reference to colorectal cancer. Existing data suggest that curcumin in combination with chemotherapy is a superior strategy for treatment of gastrointestinal cancer.

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关键词：

antineoplastic agents clinical trials colon colorectal cancer curcumin drug therapy fluorouracil human diseases neoplasms reviews

DOI：

10.1080/01635580903285106

被引量：

136

年份：

2009

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