Apoptosis and the cell cycle
摘要：
In this review, we consider apoptosis as a process intimately linked to the cell cycle. There are several reasons for thinking of apoptosis as a cell cycle phenomenon. First, within the organism, apoptosis is almost exclusively found in proliferating tissues. Second, artificial manipulation of the cell cycle can either prevent or potentiate apoptosis, depending on the point of arrest. Data from such studies have suggested that molecules acting late in G1 are required for apoptosis. Since passage through late G1 into S phase in mammalian cells is known to be regulated by p53 and by activation of cyclin-dependent kinases, we also examine recent studies linking these molecules to the apoptotic pathway.
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关键词：
Animals Humans DNA Cell Division G1 Phase Apoptosis Cell Cycle Cyclin-Dependent Kinases Tumor Suppressor Protein p53 Proto-Oncogene Proteins p21(ras
DOI：
10.1007/978-1-4615-5873-6_15
被引量：
年份：
1995
Springer
dx.doi.org
Ingenta
Europe PMC
NCBI
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