p53 and c-Jun Functionally Synergize in the Regulation of the DNA Repair Gene hMSH2 in Response to UV
摘要：
The suppresser protein is critical for guarding the genome from incorporation of damaged DNA (Lane, D. P. (1992) Nature 358, 15-16). A relevant stress that activates function is UV light (Noda, A., Toma-Aiba, Y., and Fujiwara, Y. (2000) Oncogene 19, 21-31). Another well known component of the mammalian UV response is the factor c-(Angel, P., and Karin, M. (1991) Biochim. Biophys. 1072, 129-157). We show here that upon UV irradiation activates of the gene . Interestingly, this up-regulation critically depends on functional interaction with c-. Hence, the synergistic interaction of a proto-oncogene with a suppresser gene is required for the regulation of the mammalian stress response through activation of expression of .
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关键词：
Humans Cell Line Tumor Cells, Cultured DNA DNA-Binding Proteins Proto-Oncogene Proteins Ultraviolet Rays Base Sequence Gene Expression Regulation MutS Homolog 2 Protein
DOI：
10.1074/jbc.M006990200
被引量：
年份：
2000
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