Catalytic Synthesis of Optically Active β-Amino Acid Derivatives
摘要：
In continuation to our earlier reviews on organocatalysis, a systematic approach for the synthesis of chiral β-amino acid derivatives in the presence of mainly organocatalysts and transition metal catalysts are described. Asymmetric Mannich reactions catalyzed by proline and bifunctional organocatalysts are explained, whereas metal catalysis based on hydrogenation, Mannich and conjugate additions are elaborated. The resulting β-amino carbonyl moieties are essential structural units of many natural products and are important chiral building blocks for the synthesis of nitrogen-containing bioactive molecules
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关键词：
Bifunctional organocatalysts chiral β-amino acids conjugate addition hydrogenation mannich reaction natural products pharmaceuticals proline transition metal transition metal catalysts β-peptides
DOI：
10.2174/157017912803251783
被引量：
年份：
2012
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