The First Direct and Enantioselective Cross-Aldol Reaction of Aldehydes
摘要：
The first enantioselective catalytic direct cross-aldol reaction that employs nonequivalent aldehydes has been accomplished using proline as the reaction catalyst. Structural variation in both the aldol donor (R1 = Me, n-Bu, Bn, 91 to >99%) and aldol acceptor (R2 = I-Pr, I-Bu, c-C6H11, Et, Ph, 97−99% ee) are possible while maintaining high reaction efficiency (75−88% yield). Significantly, this new aldol variant allows facile enantioselective access to a broad range of β-hydroxy aldehydes which are valuable intermediates in polyketide syntheses.
展开
DOI：
10.1021/ja0262378
被引量：
年份：
2002
Semantic Scholar
(全网免费下载)
chemlabs.princeton.edu
(全网免费下载)
eee.uci.edu
(全网免费下载)
osti.gov
(全网免费下载)
princeton.edu
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
请先登入
相似文献
参考文献
引证文献
辅助模式
0
引用
文献可以批量引用啦~
欢迎点我试用！
