Long Non-coding RNAs and Their Roles in Non-small-cell Lung Cancer

阅读量：

137

作者：

展开

摘要：

As a leading cause of cancer deaths worldwide, lung cancer is a collection of diseases with diverse etiologies which can be broadly classified into small-cell lung cancer (SCLC) andnon-small-cell lung cancer(NSCLC). Lung cancer is characterized by genomic and epigenomic alterations; however, mechanisms underlying lung tumorigenesis remain to be elucidated.Long non-coding RNAs(lncRNAs) are a group of non-coding RNAs that consist of 200 nucleotides but possess low or no protein-coding potential. Accumulating evidence indicates that abnormal expression of lncRNAs is associated with tumorigenesis of various cancers, including lung cancer, through multiple biological mechanisms involving epigenetic, transcriptional, and post-transcriptional alterations. In this review, we highlight the expression and roles of lncRNAs in NSCLC and discuss their potential clinical applications as diagnostic or prognosticbiomarkers, as well as therapeutic targets.

展开

关键词：

Long non-coding RNA Non-small-cell lung cancer Expression spectrum Biomarker Therapeutic resistance

DOI：

10.1016/j.gpb.2016.03.007

被引量：

年份：

2016