Hypothermic circulatory arrest with moderate, deep or profound hypothermic selective antegrade cerebral perfusion: which temperature provides best brain protection?
摘要：
=6) or with either 10°C (=6), 20°C (=7) or 30°C (=7) of SACP. Haemodynamics, metabolics and neurophysiology (EEG, SSEP, ICP, sagittal sinus saturation) were monitored. Animals were sacrified 4h after reperfusion and brains perfused for histological and molecular genetic assessment. =0.095). Histopathological evaluation showed a reduction of edema and eosinophilic cells in the groups treated with SACP. Conclusion: In this model, SACP is superior to HCA alone. Regarding the optimal temperature for SACP, it seems that 20°C provides adequate brain protection in comparison to the potential detrimental effects of moderate (30°C) and profound (10°C) temperatures.
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关键词：
Hypothermic circulatory arrest Selective cerebral perfusion Perfusion temperature Cerebral protection Animal model
DOI：
10.1016/j.ejcts.2006.05.031
被引量：
年份：
2006
Elsevier
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