Serine peptidase modulators

The present invention relates to new compounds having modulatory (inhibitory and stimulatory) activity on serine peptidases and proteases in general and dipeptidyl peptidase IV, prolyl oligopeptidase (PO), dipeptidyl peptidase II (DPP II...

SIMON LODEWIJK SCHARPE，INGRID ANNA JOZEF DE MEESTER，ALEXANDRE ARKADICVITCH BELIAEV，... - US

SERINE PEPTIDASE MODULATORS

The present invention relates to new compounds having modulatory (inhibitory and stimulatory) activity on serine peptidases and proteases in general and dipeptidyl peptidase IV, prolyl oligopeptidase (PO), dipeptidyl peptidase II (DPP II...

AKJ Ludovicus，BA Arkadicvitch，DMIA Jozef，...

High-affinity interleukin-4 muteins

This invention is directed to recombinant human IL-4 muteins numbered in accordance with wild-type IL-4 wherein the muteins comprise at least one amino acid substitution selected from the group consisting of substitutions at positions 13...

JM Greve，AB Shanafelt，S Roczniak

DNA encoding high affinity interleukin-4 muteins

A recombinant human IL-4 mutein numbered in accordance with wild-type IL-4 wherein the mutein comprises at least one amino acid substitution in the binding surface of either the A- or C-alpha helices of the wild-type IL-4 whereby the mut...

Jeffrey M. Greve，Armen B. Shanafelt，S Roczniak - US

Use of fermented soy extract in inhibiting vancomycin-resistant enterococci

The present invention relates to a new use of a fermented soy extracts in preventing VRE infections.

KM Lu

Treating humans by inhaling into the bronchial passageways and lungs; device for inhalation; injectable solutions; side effect reduction

Fructose-1,6-diphosphate (FDP), a sugar-phosphate compound, can be useful in treating asthma, when administered as an inhalable drug, either by itself or a...

AK Markov - US

Methods for regulating hematopoiesis using CpG-oligonucleotides

The invention relates to methods for regulating hematopoiesis using CpG containing oligonucleotides. In particular, the invention relates to methods of treating thrombopoiesis and anemia by regulating hematopoiesis. The invention also re...

H Wagner，Grayson B. Lipford - US

Use Of Platelets Or Platelet Rich Plasma(Prp)

A new use is disclosed for the content of platelets or platelet rich plasma (PRP) obtained by disruption of their membranes for the preparation of an agent for the treatment of bone, cartilage or skin.

T Meury，T Stoll，M Alini - US

Boronate Medicaments Suitable for Short Duration Anticoagulation

An oral dosage form of a compound selected from boronic acids which have a neutral thrombin (P1) domain linked to a hydrophobic moiety capable of binding to the thrombin (S2) and (S3) subsites, and salts, prodrugs and prodrug salts of su...

Guy Michael Patrick，Sophie Marie Combe-Marzelle，Anthony James Kennedy，... - US

EAR TREATMENT FOR EXCESS HAIR

The topical use of eflornithine hydrochloride on an ear to reduce or retard the growth of ear hair. Eflornithine hydrochloride is applied to an area of ear hair growth until the hair growth decreases to a desired level. Eflornithine hydr...

SA Muller - US