Crystal structure of HP0242, a hypothetical protein from Helicobaccter pylori wrath a novel fold

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[[abstract]]Helicobacter pylori is a spiral-shaped, gram-negative microorganism that was found in 1979 and isolated in 1982.[1] In 1994, the International Agency for Cancer Research declared H. pylori to be a carcinogen of human.[2] Two complete genome sequences of H. pylori, strain 26695 and strain J99, have been determined by the whole-genome random sequencing method.[3][4] About 33% protein sequences in the whole genome are annotated as hypothetical proteins whose functions and three-dimensional structures have never been identified. The better understanding of these proteins' cellular processes could provide the basis for discoveries of potential antibacterial drug targets. Therefore, the determination of the structural and functional relationship of these proteins has thus drawn much research attention.

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Helicobacter pylori Bacterial Proteins Recombinant Proteins DNA Primers X-Ray Diffraction Crystallography, X-Ray Cloning, Molecular Polymerase Chain Reaction Base Sequence Protein Conformation