ChemInform Abstract: Iridium-Catalyzed Borylation of Secondary Benzylic C-H Bonds Directed by a Hydrosilane
摘要：
Most functionalizations of C-H bonds by main-group reagents occur at aryl or methyl groups. We describe a highly regioselective borylation of secondary benzylic C-H bonds catalyzed by an iridium precursor and 3,4,7,8-tetramethyl-1,10-phenanthroline as the ligand. The reaction is directed to the benzylic position by a hydrosilyl substituent. This hydrosilyl directing group is readily deprotected or transformed to other functional groups after the borylation reaction, providing access to a diverse set of secondary benzylboronate esters by C-H borylation chemistry.
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DOI：
10.1021/ja403462b
被引量：
年份：
2013
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来源期刊
Journal of the American Chemical Society
2013/05/24
引用走势
2014
被引量：15
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