摘要：

The mono- and di-methoxy substituted benzohydroxamic acids proved to be potent antineoplastic/cytotoxic agents effectively suppressing growth in suspended tumor cells and demonstrated some selectivity against certain human carcinomas. These methoxy derivatives inhibited L1210 DNA and protein syntheses. They were metabolic inhibitors of the activities of regulatory enzymes of de novo purine and pyrimidine syntheses in L1210 lymphocytic leukemia cells after 60 min at 100 μM. Ribonucleoside reductase, dihydrofolate reductase and DNA polymerase α activities were also moderately suppressed by these agents which would add to the overall reduction of DNA synthesis as well as tumor cell growth.

展开