Individual Sensitivity to Genotoxic Effects of Nickel and Antimutagenic Activity of Ascorbic Acid
摘要：
Cytotoxicity of nickel compounds was studied by stimulating the repair synthesis of DNA and counting lymphocyte micronuclei in workers of smelting shop of copper-nickel sulfide processing plant. Nickel content in the organism was evaluated by its concentrations in hair. Therapy with ascorbic acid (1 g/day for 1 month) led to a significant decrease in the number of micronuclei. The number of micronuclei before and after ascorbic acid treatment varied within a wide range in different individuals.
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关键词：
nickel professional exposure micronuclei repair DNA synthesis ascorbic acid individual sensitivity
DOI：
10.1023/A:1017912521543
被引量：
年份：
2001
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