Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors
摘要：
We report here the purification of a cytosolic protein that induces cytochrome c release from mitochondria in response to caspase-8, the apical caspase activated by cell surface death receptors such as Fas and TNF. Peptide mass fingerprinting identified this protein as Bid, a BH3 domain-containing protein known to interact with both Bcl2 and Bax. Caspase-8 cleaves Bid, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Immunodepletion of Bid from cell extracts eliminated the cytochrome c releasing activity. The cytochrome c releasing activity of Bid was antagonized by Bcl2. A mutation at the BH3 domain diminished its cytochrome c releasing activity. Bid, therefore, relays an apoptotic signal from the cell surface to mitochondria.
展开
关键词：
pH regulation volume regulation Cl channel H+ pump Leishmania Trypanosome Crithidia Herpetomona
DOI：
10.1016/S0092-8674(00)81589-5
被引量：
年份：
1998
Elsevier
Taylor & Francis
BMJ
万方医学
dx.doi.org
查看更多
Cell Press
(全网免费下载)
NCBI
Cell Press
NCBI
Europe PMC
ResearchGate
EureKaMag.com
(全网免费下载)
EBSCO
Citeseer
mysciencework.com
cghjournal.org
readcube.com
jlr.org
molbiolcell.org
infona.pl
ajpgi.physiology.org
science-open.com
jcs.biologists.org
computersinbiologyandmedicine.com
jpet.aspetjournals.org
reproduction-online.org
jacionline.org
mendeley.com
jcb.rupress.org
emboj.embopress.org
clinicalmicrobiologyandinfection.com
fertstert.org
scienceopen.com
core.ac.uk
mct.aacrjournals.org
augusta.pure.elsevier.com
Cell Press
(全网免费下载)
EureKaMag.com
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
