Continuous Activation of Autoreactive CD4+ CD25+ Regulatory T Cells in the Steady State
摘要：
Despite a growing interest in CD4+CD25+regulatory T cells (Treg) that play a major role in self-tolerance and immunoregulation, fundamental parameters of the biology and homeostasis of these cells are poorly known. Here, we show that this population is composed of two Tregsubsets that have distinct phenotypes and homeostasis in normal unmanipulated mice. In the steady state, some Tregremain quiescent and have a long lifespan, in the order of months, whereas the other Tregare dividing extensively and express multiple activation markers. After adoptive transfer, tissue-specific Tregrapidly divide and expand preferentially in lymph nodes draining their target self-antigens. These results reveal the existence of a cycling Tregsubset composed of autoreactive Tregthat are continuously activated by tissue self-antigens.
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DOI：
10.1084/jem.20030686
被引量：
年份：
2003
国家科技图书文献中心
(权威机构)
Semantic Scholar
万方医学
掌桥科研
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