摘要：

The carcinogenic response to the combined and separate exposures to (HCHO) and (HCl) was investigated in male inbred SD . The were exposed to gaseous HCHO, 14 ppm, and HCl, 10 ppm, in two experiments. In one experiment the gases were premixed at high concentrations before being diluted in the exposure chamber air to maximize the of the carcinogen (BCME). In the second experiment exposure was repeated to HCl and HCHO premixed at high concentrations, and not premixed (to minimize BCME ), as well as to HCHO alone and HCl alone. The second experiment is being reported on at an interim stage. HCHO alone induced of the nasal cavity as did the combined exposures to HCHO and HCl. No carcinogenic response was observed with HCl alone. HCHO accounted for most, if not all, of the carcinogenic activity of the mixture of HCHO-HCl.

展开