The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate.
摘要：
1The interaction of two dissociative anaesthetics, ketamine and phencyclidine, with the responses of spinal neurones to the electrophoretic administration of amino acids and acetylcholine was studied in decerebrate or pentobarbitone-anaesthetized cats and rats.2Both ketamine and phencyclidine selectively blocked excitation by N-methyl-aspartate (NMA) with little effect on excitation by quisqualate and kainate.3Ketamine reduced responses to L-aspartate somewhat more than those of l-glutamate; the sensitivity of responses to these two putative transmitters was between that to NMA on one hand and that to quisqualate or kainate on the other.4On Renshaw cells, ketamine and phencyclidine reduced responses to acetylcholine less than those to NMA but more than those to quisqualate or kainate. Dorsal root-evoked synaptic excitation of Renshaw cells was reduced to a greater extent than that following ventral root excitation.5Intravenous ketamine, 2.520 mg/kg, and phencyclidine, 0.20.5 mg/kg, also selectively blocked excitation of neurones by NMA.6Ketamine showed no consistent or selective effect on inhibition of spinal neurones by electrophoretically administered glycine or -aminobutyricacid (GABA).7The results suggest that reduction of synaptic excitation mediated via NMA receptors contributes to the anaesthetic/analgesic properties of these two dissociative anaesthetics.
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DOI：
10.1111/j.1476-5381.1983.tb11031.x
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年份：
1983
Wiley
Wiley
Wiley
万方医学
掌桥科研
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