Immunological Classification of Acute Lymphoblastic Leukaemias: Evaluation of its Clinical Significance in a Hundred Patients
摘要：
S ummary . The use of T and B lymphocyte markers and of different antisera raised against malignant B cells and fetal thymocytes allowed the classification of 100 patients with acute lymphoblastic leukaemia (ALL) into three groups. (1) Patients with non-T non-B ALL whose cells were devoid of conventional B and T markers but characterized by a leukaemia associated antigen (69 cases). (2) Patients with T-derived ALL (28 cases). (3) Patients with ALL of B cell origin (three cases). The search for haematological and clinical correlations showed that those patients with T-derived ALL tended to have a higher leucocyte count ( P = 0.05) and acid phosphatase positivity of blast cells ( P = 0.01), a higher incidence of tumour presentation ( P = 0.05) and a thymic mass. Survival curves for the two main groups of patients are similar at 36 months but meningeal relapses were more frequent in patients with T-derived ALL ( P = 0.02).
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DOI：
10.1111/j.1365-2141.1976.tb03547.x
被引量：
年份：
1976
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