Epithelial cell specialization within human Peyer's patches: an ultrastructural study of intestinal lymphoid follicles.
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100
摘要：
The 'M' (microfold) cell, a previously unrecognized human intestinal mucosal cell type, is described from studies by light microscopy, transmission electron microscopy, and scanning electron microscopy. M cells, characterized by luminal surface microfolds rather than microvilli, are located in areas of noncolumnar epithelium overlying lymphoid follicles in Peyer's patches. Attenuated M cell processes form a latticework, allowing lymphoid cells to approach to within 0.3 μm of the intestinal lumen while maintaining the integrity of the intestinal epithelium. These newly discovered epithelial cells contain multiple vesicles that suggest a transport function, possibly for luminal antigenic material or for secretory immunoglobulin.
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关键词：
Humans Lymphoid Tissue Peyer's Patches Intestinal Mucosa Ileum Epithelial Cells Microscopy Microscopy, Electron Adult Microscopy, Electron, Scanning
DOI：
10.1016/S0016-5085(74)80102-2
被引量：
年份：
1974
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