Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations
摘要：
One important goal of asthma treatment is to reduce exacerbations. The current authors investigated if the use of sputum cell counts to guide treatment would achieve this goal. A total of 117 adults with asthma were entered into a multicentre, randomised, parallel group-effectiveness study for two treatment strategies over a 2-yr period. In one strategy (the clinical strategy: CS) treatment was based on symptoms and spirometry. In the other (the sputum strategy: SS) sputum cell counts were used to guide corticosteroid therapy to keep eosinophils 250 microg, and was due to fewer eosinophilic exacerbations. The cumulative dose of corticosteroid during the trial was similar in both groups. Monitoring sputum cell counts was found to benefit patients with moderate-to-severe asthma by reducing the number of eosinophilic exacerbations and by reducing the severity of both eosinophilic and noneosinophilic exacerbations without increasing the total corticosteroid dose. It had no influence on the frequency of noneosinophilic exacerbations, which were the most common exacerbations.
展开
DOI：
10.1183/09031936.06.00137704
被引量：
年份：
2006
BMJ
Wiley
万方医学
Semantic Scholar
(全网免费下载)
dx.doi.org
查看更多
NCBI
NCBI
Europe PMC
The Lancet
ResearchGate
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
ersj.org.uk
学术范
deepdyve.com
nejm.org
mendeley.com
学术范
(全网免费下载)
jacionline.org
pediatrics.aappublications.org
erj.ersjournals.com
jaci-inpractice.org
erj.ersjournals.com
(全网免费下载)
ers-education.org
onAcademic
ersj.org.uk
(全网免费下载)
mysciencework.com
Semantic Scholar
(全网免费下载)
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
erj.ersjournals.com
(全网免费下载)
ersj.org.uk
(全网免费下载)
学术范
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
