GammaH2AX and cancer.
摘要：
Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus (producing gammaH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may lead to cancer but, paradoxically, are also used to kill cancer cells. Using gammaH2AX detection to determine the extent of DSB induction may help to detect precancerous cells, to stage cancers, to monitor the effectiveness of cancer therapies and to develop novel anticancer drugs.
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关键词：
Animals Mammals Humans Mice Antineoplastic Agents Histones Sequence Alignment Signal Transduction Protein Conformation Sequence Homology, Amino Acid
DOI：
10.1038/nrc2523
被引量：
年份：
2008
Nature
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