Role of Nonexercise Activity Thermogenesis in Resistance to Fat Gain in Humans
摘要：
Humans show considerable interindividual variation in susceptibility to weight gain in response to overeating. The physiological basis of this variation was investigated by measuring changes in energy storage and expenditure in 16 nonobese volunteers who were fed 1000 kilocalories per day in excess of weight-maintenance requirements for 8 weeks. Two-thirds of the increases in total daily energy expenditure was due to increased nonexercise activity thermogenesis (NEAT), which is associated with fidgeting, maintenance of posture, and other physical activities of daily life. Changes in NEAT accounted for the 10-fold differences in fat storage that occurred and directly predicted resistance to fat gain with overfeeding (correlation coefficient = 0.77, probability < 0.001). These results suggest that as humans overeat, activation of NEAT dissipates excess energy to preserve leanness and that failure to activate NEAT may result in ready fat gain.
展开
关键词：
Humans Adipose Tissue Basal Metabolism Exercise Energy Metabolism Energy Intake Posture Body Composition Hyperphagia Adult
DOI：
10.1126/science.283.5399.212
被引量：
年份：
1999
万方医学
dx.doi.org
Oxford Univ Press
NCBI
Europe PMC
查看更多
NCBI
JSTOR
NRC Research Press
JBC
AGRIS
dialnet.unirioja.es
ProQuest
ResearchGate
(全网免费下载)
ResearchGate
EBSCO
Citeseer
(全网免费下载)
EBSCO
obesitysolutions.asu.edu
(全网免费下载)
ajpendo.physiology.org
joe.endocrinology-journals.org
readcube.com
ajp.psychiatryonline.org
genetics.org
press.endocrine.org
www.socolar.com
onacademic.com
pediatrics.aappublications.org
science.sciencemag.org
(全网免费下载)
sciencemag.org
jlr.org
jpet.aspetjournals.org
biochem4.okstate.edu
(全网免费下载)
cjasn.asnjournals.org
ejinme.com
mendeley.com
hyper.ahajournals.org
diabetes.diabetesjournals.org
go.galegroup.com
SAGE
baywood.metapress.com
highbeam.com
pubfacts.com
scienceopen.com
jn.nutrition.org
jrheum.org
asu.pure.elsevier.com
sciencepubs.com
ganino.com
(全网免费下载)
gruvetechnologies.com
(全网免费下载)
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
science.sciencemag.org
(全网免费下载)
biochem4.okstate.edu
(全网免费下载)
ganino.com
(全网免费下载)
gruvetechnologies.com
(全网免费下载)
obesitysolutions.asu.edu
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
