摘要：

Reports the results of the cloning of a complementary DNA encoding a protein SOCS-1, containing a SH2-domain, by its ability to inhibit the macrophage differentiation of M1 cells in response to interleukin-6. The inhibition of both interleukin-6-induced receptor phosphorylation and the activation of the STAT family of transcription factors; The possible role of the SOCS genes in the regulation of cytokine signal transduction.

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