Discovery of new peptide-Based catalysts for the direct asymmetric aldol reaction
摘要：
A series of oligo-peptide based catalysts were prepared using Fmoc solid-phase peptide synthesis. It was found that peptides with N-terminal proline residues catalyzed an aldol reaction yielding enantiomeric enriched product. Peptide H-Pro-Glu-Leu-Phe-OH catalyzed the reaction with good activity and moderate enantioselectivity (66% ee). Furthermore, it was shown that an acidic side chain and/or C-termini are essential to catalysis.
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关键词：
diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism C‐C bond formation catalysis, phase‐transfer catalysis amino acids, peptides
DOI：
10.1016/S0960-894X(03)00498-0
被引量：
年份：
2003
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