Localization of the X inactivation centre on the human X chromosome in Xq13

来自 NCBI

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阅读量：

5161

作者：

CJ Brown，RG Lafreniere，VE Powers，G Sebastio，HF Willard

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摘要：

X-CHROMOSOME inactivation results in the strictly cis -limited inactivation of many but not all genes on one of the two X chromosomes during early development in somatic cells of mammalian females 1 . One feature of virtually all models of X inactivation is the existence of an X-inactivation centre ( XIC ) required in cis for inactivation to occur 2–5 . This concept predicts that all structurally abnormal X chromosomes capable of being inactivated have in common a defineable region of the X chromosome 6–8 . Here we report an analysis of several such rearranged human X chromosomes and define a minimal region of overlap. The results are consistent with models invoking a single XIC and provide a molecular foothold for cloning and analysing the XIC region. One of the markers that defines this region is the XIST gene 9 , which is expressed specifically from inactive, but not active, X chromosomes. The localization of the XIST gene to the XIC region on the human X chromosome implicates XIST in some aspect of X inactivation.

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关键词：

X Chromosome Humans Chromosome Mapping Gene Rearrangement Dosage Compensation, Genetic

DOI：

10.1038/349082a0

被引量：

1005

年份：

1991