The survival kinases Akt and Pim as potential pharmacological targets
摘要：
The Akt and Pim kinases are cytoplasmic serine/threonine kinases that control programmed cell death by phosphorylating substrates that regulate both apoptosis and cellular metabolism. The PI3K-dependent activation of the Akt kinases and the JAK/STAT-dependent induction of the Pim kinases are examples of partially overlapping survival kinase pathways. Pharmacological manipulation of such kinases could have a major impact on the treatment of a wide variety of human diseases including cancer, inflammatory disorders, and ischemic diseases.
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DOI：
10.1172/JCI26273
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年份：
2005
Taylor & Francis
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来源期刊
Journal of Clinical Investigation
2005 Oct;
引用走势
2012
被引量：102
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