摘要：

Tumors on flathead sole in East Sound, Orcas Island, Washington, showed a very orderly sequence of tumorigenesis both in the field and laboratory. Only fish age 12 months or less had angioepithelial nodules (AEN), fish 813 months had transitional stages, and the earliest epidermal papillomas (EP) were on 10-month-old fish. Nearly all tumor-bearing fish in age-groups I III had EP. The greatest number of tumors (45 AEN per fish) occurred on the youngest fish and steadily declined with age until by about 14 months the average number of EP was 12. There were significantly more AEN on the eyed than on the blind side of the fish, suggesting that the tumorigenic event(s) occurred at, or shortly after, metamorphosis.

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