Adenosine A2 receptors interact negatively with dopamine D1 and D2 receptors in unilaterally 6-hydroxydopamine-lesioned rats.
摘要：
In rats bearing a unilateral 6-hydroxydopamine lesion of the dopaminergic nigro-striatal pathway, stimulation of adenosine A 2 receptors by CGS 21680 reduced the contralateral turning behavior induced by L -3,4-dihydroxyphenylalanine (L-DOPA). Administration of CGS 21680 completely blocked the contralateral turning induced by the dopamine D 1 receptor agonist, SKF 38393, and reduced the turning induced by the dopamine D 2 receptor agonist, LY 171555. Quinolinic acid lesion of the striatum or 6-hydroxydopamine lesion of the dopaminergic nigro-striatal neurons demonstrated that [ 3 H]CGS 21680 binding sites are associated to striatal intrinsic neurons. This study provides evidence for a negative postsynaptic interaction of both dopamine D 1 and D 2 receptors with adenosine A 2 receptors.
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DOI：
10.1016/0014-2999(94)90438-3
被引量：
年份：
1994
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